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Medical therapies for IBD include oral or rectal 5-ASA drugs, immunomodulators, biologicals, and other newer agents with different targets and mechanisms of action For patients with mild to moderate UC, 5-ASA drugs are effective for achieving remission and maintenance Rarely, patients have serious adverse events with 5-ASA drugs (eg, interstitial nephritis, pericarditis, pneumonitis, hepatitis, or pancreatitis) Antibiotics Controlled trials of various antibiotics have not demonstrated efficacy in treating UC

Several PRRs have a selective ability to detect PAMPs, such as Toll-like receptors (TLRs) and also retinoic acid-inducible gene 1 (RIG 1)-like receptors (RLRs) [58]

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